Ultrasound Targeted Gene Delivery

Ultrasound Targeted Gene Delivery

SONIDEL MB101®

Microbubble

SONIDEL MB101® Microbubble

Optimised for enhanced ultrasound-mediated gene transfer

  • Polymer-stabilized, lipid-based microbubble
  • Neutral surface charge and PEGylated for reduced non-specific binding
  • Sterile, liquid preparation
  • Ready to use with no requirement for specialised mixing devices
  • Stable for 6 months at 40C
  • Optimized for use with the SONIDEL SP100 sonoporator
  • Designed specifically for ultrasound-mediated gene transfection / Nucleic Acid Transfer using in vivo and in vitro target systems
  • Non-invasive stimulation of gene transfer
  • Efficient gene/nucleic acid transfer
  • In vivo and in vitro applications
  • Compatible for use with plasmids and minicircle DNA
  • Minimal impact on cell/tissue viability
  • Supplied as part of the SONIDEL STK10 ultrasound transfection kit or as individual pack

SONIDEL MB101® Microbubble Photographic Results

After using the SONIDEL SP100 sonoporation system
Plasmid DNA – pCMV-Luc
Minicircle DNA – MC07.CMV-luc
MB+DNA
MB+DNA+US
DNA+US
MB+DNA
MB+DNA+US
DNA+US
Plus MB101
No MB101
Plus MB101
No MB101

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Luciferase Expression using MB101 In Vivo (pCMV-luc and MC07.CMV-luc)

Cells Sonoporated in 3-D Matrix
Adherent Cells in Opticell ®

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