Ultrasound Gene Transfer: One System for Non-invasive in vitro and in vivo applications

Ultrasound Gene Transfer: One System for Non-invasive in vitro and in vivo applications

96 Well Plate Ultrasound Exposure Configuration

High Throughput Screening Capability

96 well plate ultrasound exposure configuration - High throughput screening capability

·    Rapid quantitative bioluminescent imaging of luciferase expression in a 96-well configuration

·    Compatible with high throughput screening

·    No interaction between ultrasonic probe and culture media

·    No compromise in sterility

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Opticell® Ultrasound Exposure Configuration

Spatial Resolution Studies

SP100 - Opticell ultrasound exposure configuration - Spatial resolution studiesSP100 - Opticell ultrasound exposure configuration - Spatial resolution studies - side colour bar

·    Spatial resolution of ultrasound-stimulated gene expression in an Opticell® configuration

·    Using bioluminescent imaging

·    Self-contained culture system
·    No direct connection between ultrasonic probe and culture media

·    Reduced contamination risk

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MB101 Microbubble-Enhanced Ultrasound-mediated Gene Transfer

Non-Invasive Stimulation of Site-Specific Gene Expression

Mice - MB101, MB101 with US, no MB101 only US

MB101                  MB101 + U/S                        U/S

·    Efficient non-invasive stimulation of gene expression

·    Quantitative determination of gene expression using bioluminescent imaging

·    Comparable with electroporation WITHOUT the necessity for sophisticated electrode configurations

·    Microbubble component (MB101) is highly response to ultrasound

·    MB101 enhances ultrasound-mediated transient cell membrane permeabilisation at the target site

·    Microbubble component can serve as a carrier for nucleic acid and other active agents

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Please feel free to contact us at: sales@sonidel.com

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