Electrochemotherapy for digital chondrosarcoma

Electrochemotherapy for digital chondrosarcoma

NEPA21 / CUY21 Applications

[Cancer Therapy] Electrochemotherapy for digital chondrosarcoma.

a. Proximal phalanx of the middle finger is swollen.

b. Expanding radiolucent mass in the proximal phalangeal bone.

c. No recurrence was seen even 3 years after treatment.

Biopsy specimen.

a) Cells varying in size and shape with nuclear atypia and multivesicular vacuolation of cytoplasm.

b) Two weeks after electrochemotherapy, histological analysis of core needle biopsies revealed 90% tumor cell necrosis

H&E x 200

Electrode and electroporation.

a. Stainless steel 3cm x 5cm electrodes.

b. Electroporation with two parallel

electrodes placed on opposite

sides of the tumor

Resistance Measurement: 245±101Ω

Voltage: 150V (Electric field strength: 50/cm)

Current: 1.1±0.5A

Pulses:

4 pulses of 250ms (On: 50ms, Off: 200ms)

6 pulses of 167ms (On: 50ms, Off: 117ms)

Gross and microscopic findings of the resected tumor.

a) Gross appearance of marginally resected tumor.

b) Cut surface.

c) Microphotograph of the central portion of the tumor (area c in panel b).

d) Peripheral region (area d in panel b).

H&E x 200

A histological study of the resected tumor showed necrosis at the tumor margin.

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